Configurational
and conformational isomers have a three-dimensional structures, and is not easy
to depict on a paper having only two dimensions. To overcome this problem, the
following four two-dimensional structures known as projections have been
evolved.
· Fischer
Projection
· Newman
Projection
· Sawhorse
Projection
· Flying
Wedge Projection
A.
Fischer
Projection:
Fischer
projections are always generated by orienting the molecules in such a manner
that vertical bonds connected to the chirality centre are directed away from
the viewer, and the horizontal bonds point towards the viewer. On paper, the
projection of bonds is in shape of a cross with the chiral centre at the centre
of the cross.
Fischer
projection of one stereoisomer of glyceric acid ( HOOC-CHOH-CH2OH)
is shown below.
Characteristics Features
of Fischer Projection:
(i) Fischer projection
of a chiral molecule can be changed into another identical Fischer projection
by interchanging the position of any two pairs of substituents generates the
identical structure.
(ii)
Rotation of a Fischer projection by an angle of 180o about the axis which is
perpendicular to the plane of the paper gives identical structure.
B.
Newman
Projection:
In
Newman projection, the molecule is looked from down the length of a particular
carbon-carbon bond. The carbon atom away from the viewer is called rear carbon,
and is represented by a circle. The carbon atom away from the viewer is called
rear carbon, and is represented by a circle. The carbon atom facing the viewer
is called front carbon, and is represented as the centre of the above circle,
which is shown by a dot. The remaining bonds on each carbon are shown by small
straight lines at angles of 120o as follows:
a.
Bonds joined to front carbon intersect at the
central dot.
b. Bonds joined to rear carbon are shown as
emanating from the circumference of the circle.
Staggered and eclipsed conformations arise due to free
rotation about the carbon-carbon single bond ( front and rear carbon atoms).
C.
Sawhorse
Projection:
In this
projection, the bond between two carbon atoms is shown by a longer diagonal
line, because we look at this bond from an oblique angle. The bonds linking
other substituents to these carbons are shown projecting above and below this
line. Thus, Sawhorse projection of staggered and eclipsed conformations of
n-butane can be drawn as follows:
Due to
free rotation along the central bond, two extreme conformations are possible,
staggered and eclipsed.
D. Flying
Wedge Projection:
It is a
three-dimensional representation, and is particularly useful for chiral
molecules. The procedure for drawing this type of projection formula is as
follows:
Out of
four bonds connecting substituents to a chiral carbon, two bonds are drawn in
the plane of the paper, which is shown by normal lines, third bond lies above this
plane, which is shown by a solid cone and the fourth bond lies below the plane
of the paper which is shown by broken lines. The flying wedge formulae of two
enantiomeric lactic acid are shown below.
Both
these structures are mirror images of each other. In such representation, the
main functional group is, generally, held on the upper side in the vertical
plane.
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